GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs3772130 | 1 | rs62268732 | chr3:121370455 | IQCB1 | chr3:121488610-121553926:- | 0.53 | 10.21 | 2.95E-22 | Cognitive performance |
| THCA | cis | rs10935120 | 1 | rs62269547 | chr3:134214042 | ANAPC13 | chr3:134196547-134204865:- | 0.39 | 12.57 | 1.72E-31 | Height |
| THCA | cis | rs10935120 | 1 | rs62269547 | chr3:134214042 | CEP63 | chr3:134204575-134293852:+ | 0.29 | 6.4 | 3.83E-10 | Height |
| THCA | cis | rs10935120 | 1 | rs62271513 | chr3:134298412 | ANAPC13 | chr3:134196547-134204865:- | -0.37 | -11.34 | 1.51E-26 | Height |
| THCA | cis | rs10935120 | 1 | rs62271513 | chr3:134298412 | CEP63 | chr3:134204575-134293852:+ | -0.3 | -6.49 | 2.16E-10 | Height |
| THCA | cis | rs10935120 | 1 | rs62271514 | chr3:134298554 | ANAPC13 | chr3:134196547-134204865:- | -0.37 | -11.34 | 1.51E-26 | Height |
| THCA | cis | rs10935120 | 1 | rs62271514 | chr3:134298554 | CEP63 | chr3:134204575-134293852:+ | -0.3 | -6.49 | 2.16E-10 | Height |
| THCA | cis | rs10935120 | 1 | rs62271515 | chr3:134300507 | ANAPC13 | chr3:134196547-134204865:- | 0.37 | 11.55 | 2.1E-27 | Height |
| THCA | cis | rs10935120 | 1 | rs62271515 | chr3:134300507 | CEP63 | chr3:134204575-134293852:+ | 0.29 | 6.27 | 8.23E-10 | Height |
| THCA | cis | rs7606754 | 1 | rs62279162 | chr2:228162280 | MFF | chr2:228189978-228222547:+ | 0.23 | 4.92 | 1.19E-6 | Corneal structure |
| THCA | cis | rs7606754 | 1 | rs62279163 | chr2:228168099 | MFF | chr2:228189978-228222547:+ | 0.22 | 4.75 | 2.76E-6 | Corneal structure |
| THCA | cis | rs9790314 | 1 | rs62279921 | chr3:161065441 | NMD3 | chr3:160939099-160971319:+ | -0.1 | -3.34 | 0.000896 | Morning vs. evening chronotype |
| THCA | cis | rs12107539 | 1 | rs62283022 | chr3:151005481 | GPR87 | chr3:151011876-151034636:- | 0.21 | 4.71 | 3.3E-6 | Lung function (forced expiratory flow between 25% and 75% of forced vital capacity) |
| THCA | cis | rs12107539 | 1 | rs62283022 | chr3:151005481 | P2RY14 | chr3:150929905-150996230:- | -0.2 | -4.19 | 3.31E-5 | Lung function (forced expiratory flow between 25% and 75% of forced vital capacity) |
| THCA | cis | rs1008375 | 1 | rs62295634 | chr4:17685346 | MED28 | chr4:17616273-17629791:+ | 0.16 | 3.42 | 0.000687 | Parasitemia in Tripanosoma cruzi seropositivity |